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Chapter 1: Vaccine Immunity Developments

Greetings! It’s time for another monthly recap from Microbial Instincts, an independent source dedicated to infectious diseases and vaccines, featuring insightful articles that are hard to find elsewhere. Below are brief summaries of articles published in September 2021 aimed at keeping you well-informed on scientific matters.

Hybrid Immunity: A Potential Solution to SARS-CoV-2 Evolution

Recent discussions highlight the advantages of both natural and vaccine-induced immunity. While vaccine immunity tends to be more targeted and effective against the original SARS-CoV-2 strain, natural immunity shows variability and may offer some level of protection against emerging variants. The concept of hybrid immunity, which combines both natural and vaccine-induced responses, presents an intriguing possibility. This immunity can be attained through mixed vaccination strategies, prompting us to reconsider whether a third dose of the same vaccine is the optimal approach.

Graphical representation of hybrid immunity benefits

Source: Shin Jie Yong in “Hybrid Immunity: A Potential Solution to SARS-CoV-2 Evolution”. This article compares mixed vaccine regimens with traditional vaccination methods in generating antibody responses to SARS-CoV-2 variants.

Understanding Vaccine Boosters

In his article, Ryan P. Gilley, Ph.D., discusses the various vaccine boosters that many of us have received for diseases like influenza, tetanus, and hepatitis A. He draws parallels to the Covid-19 vaccine, suggesting that we might see a series of 3 to 4 shots over the initial 1 to 2 years, followed by boosters every 5 to 10 years. This perspective provides a fascinating look at the potential future landscape of Covid-19 vaccinations.

Chapter 2: Vaccine Safety and Risks

mRNA Vaccine Safety: A Year On

It's been nearly a year since the emergency use authorization of the Covid-19 mRNA vaccines by Pfizer and Moderna. This section reviews three significant observational studies from the U.S., U.K., and Israel that have evaluated mRNA vaccine safety beyond clinical trials. The findings from these studies are crucial for understanding the long-term implications of these vaccines.

Heart Inflammation Risks Associated with mRNA Vaccines

Building on the previous discussion, this article delves into the heart inflammation linked to mRNA vaccines, particularly in younger males. It provides a clear risk-benefit analysis and outlines several precautions that could minimize the risk of myocarditis. The article also explores potential causes, including accidental vein penetration during injection and molecular mimicry.

Chapter 3: Vigilante Treatments in the Pandemic

The Rise and Fall of Ivermectin

David Lee Hill examines how misinformation surrounding ivermectin transformed it into a widely touted miracle drug during the pandemic. Despite emerging evidence of fraudulent studies supporting its use, belief in ivermectin persists. The article discusses how cognitive biases and hidden agendas have contributed to this situation.

Unconventional Treatments: A Risky Behavior

David also addresses the troubling trend of individuals resorting to unverified treatments like hydrogen peroxide in an attempt to combat Covid-19. Such behaviors mirror childish mischief, as society grapples with the refusal to adopt proven preventive measures.

Chapter 4: The Immune System and Covid-19

When Covid-19 Compromises Immunity

Stephanie Jyet Quan Loo clarifies how the immune system responds to a SARS-CoV-2 infection, detailing the transition from early innate responses to later adaptive ones. She highlights where the immune response can falter and how SARS-CoV-2 can evade detection, thus complicating our ability to control its replication.

The Importance of Microbes in Rainwater

In a more lighthearted contribution, Nina Vinot explores how rainwater, rich in microbes, supports plant microbiomes. This article emphasizes the crucial role of microbial diversity in maintaining health, drawing attention to its decline in our modern environment.

Representation of microbial diversity in rainwater

Source: Stephanie Jyet Quan Loo in “When Covid-19 Compromises Immunity: Understanding the Mechanisms”.

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